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. 2012 Sep 6;7(9):e44520. doi: 10.1371/journal.pone.0044520

Table 2. Association of KLK4 SNPs and prostate tumour aggressiveness.

SNP Genotype Gleason <7 Gleason ≥7 Adjusted
Chr positiona n (%) n (%) OR (95% CI) P
rs17714461 GG 241 (75.1) 640 (76.9) 1.00
56116918 GA 77 (24.0) 257 (22.4) 0.86 (0.63–1.17) 0.340
AA 3 (0.9) 7 (0.6) 0.60 (0.13–2.73) 0.510
Per A allele 0.85 (0.64–1.13) 0.269
rs17714450 GG 316 (98.8) 813 (98.7) 1.00
56115669 GA 4 (1.3) 11 (1.3) 1.05 (0.33–3.34) 0.936
AA 0 (0.0) 0 (0.0) N/A N/A
Per A allele 1.05 (0.33–3.34) 0.936
rs8101572 AA 106 (33.1) 246 (29.8) 1.00
56115440 AC 154 (48.1) 417 (50.5) 1.14 (0.85–1.53) 0.397
CC 60 (18.8) 162 (19.6) 1.12 (0.77–1.63) 0.563
Per C allele 1.07 (0.89–1.29) 0.494
rs8100631 GG 125 (39.1) 301 (36.5) 1.00
56115358 GA 145 (45.3) 393 (47.7) 1.10 (0.83–1.46) 0.506
AA 50 (15.6) 130 (15.8) 1.05 (0.71–1.55) 0.817
Per A allele 1.04 (0.86–1.25) 0.685
rs268920c CC 320 (100.0) 824 (99.9) 1.00
56114746 CG 0 (0.0) 1 (0.1) N/A N/A
GG 0 (0.0) 0 (0.0) N/A N/A
Per G allele N/A N/A
rs10427094 CC 292 (91.8) 717 (90.4) 1.00
56114689 CT 26 (8.2) 75 (9.5) 1.16 (0.72–1.85) 0.540
TT 0 (0.0) 1 (0.1) N/A N/A
Per T allele 1.19 (0.75–1.89) 0.466
rs268921 CC 123 (38.4) 297 (36.0) 1.00
56114503 CG 144 (45.0) 395 (47.9) 1.11 (0.83–1.48) 0.476
GG 53 (16.6) 133 (16.1) 1.01 (0.69–1.48) 0.974
Per G allele 1.02 (0.85–1.23) 0.806
rs268923 AA 113 (36.8) 297 (37.4) 1.00
56114028 AT 140 (45.6) 390 (49.1) 1.04 (0.78–1.40) 0.778
TT 54 (17.6) 108 (13.6) 0.75 (0.51–1.12) 0.163
Per T allele 0.90 (0.74–1.09) 0.293
rs10419776 CC 190 (79.2) 414 (73.8) 1.00
56113695 CG 49 (20.4) 138 (24.6) 1.23 (0.85–1.79) 0.273
GG 1 (0.4) 9 (1.6) 3.70 (0.46–29.58) 0.217
Per G allele 1.31 (0.93–1.85) 0.128
rs56112930 CC 312 (99.7) 804 (99.6) 1.00
56112295 CT 1 (0.3) 3 (0.4) 1.34 (0.14–13.06) 0.803
TT 0 (0.0) 0 (0.0) N/A N/A
Per T allele 1.34 (0.14–13.06) 0.803
rs7248321b AA 303 (90.4) 762 (91.0) 1.00
56110317 AG 31 (9.3) 75 (9.0) 0.93 (0.60–1.44) 0.741
GG 1 (0.3) 0 (0.0) N/A N/A
Per G allele 0.87 (0.56–1.33) 0.516
rs2569526 AA 318 (99.7) 792 (99.7) 1.00
56106299 AG 1 (0.3) 2 (0.3) 1.14 (0.10–12.82) 0.913
GG 0 (0.0) 0 (0.0) N/A N/A
Per G allele 1.14 (0.1–12.82) 0.913
rs2978642 TT 184 (57.9) 475 (57.6) 1.00
56105718 TA 112 (35.2) 297 (36.0) 1.02 (0.77–1.35) 0.893
AA 22 (6.9) 52 (6.3) 0.94 (0.55–1.59) 0.806
Per A allele 0.99 (0.80–1.22) 0.938
rs198969b GG 84 (25.1) 231 (27.6) 1.00
56105614 GC 166 (49.6) 404 (48.3) 0.87 (0.64–1.19) 0.382
CC 85 (25.4) 202 (24.1) 0.84 (0.59–1.20) 0.333
Per C allele 0.91 (0.77–1.09) 0.328
rs2242669 CC 209 (66.8) 557 (69.1) 1.00
56105602 CT 96 (30.7) 224 (27.8) 0.87 (0.65–1.15) 0.326
TT 8 (2.6) 26 (3.1) 1.16 (0.51–2.62) 0.728
Per T allele 0.93 (0.73–1.19) 0.560
rs198968 b CC 199 (60.5) 553 (66.0) 1.00
56105140 CT 111 (33.7) 266 (31.7) 0.87 (0.66–1.15) 0.342
TT 19 (5.8) 19 (2.3) 0.36 (0.18–0.69) 0.002
Per T allele 0.76 (0.60–0.95) 0.016
rs198967 CC 319 (99.7) 824 (99.9) 1.00
56104833 CT 1 (0.3) 1 (0.1) 0.56 (0.03–9.16) 0.686
TT 0 (0.0) 0 (0.0) N/A N/A
Per T allele 0.56 (0.03–9.16) 0.686
rs1654551 TT 269 (84.1) 709 (85.9) 1.00
56104480 TG 50 (15.6) 112 (13.6) 0.84 (0.59–1.22) 0.364
GG 1 (0.3) 4 (0.5) 1.32 (0.14–12.00) 0.807
Per G allele 0.87 (0.62–1.23) 0.439
rs1654552 GG 98 (30.6) 247 (30.0) 1.00
56104478 GT 163 (50.9) 405 (49.2) 1.00 (0.74–1.35) 0.997
TT 59 (18.4) 172 (20.9) 1.18 (0.81–1.73) 0.383
Per T allele 1.08 (0.89–1.30) 0.431
rs2242670b CC 90 (26.8) 236 (28.1) 1.00
56104127 CT 172 (51.2) 425 (50.6) 0.95 (0.70–1.28) 0.722
TT 74 (22.0) 179 (21.3) 0.91 (0.63–1.31) 0.607
Per T allele 0.95 (0.79–1.14) 0.603
rs198966 CC 319 (99.7) 824 (99.9) 1.00
56103822 CT 1 (0.3) 1 (0.1) 0.56 (0.03–9.16) 0.686
TT 0 (0.0) 0 (0.0) N/A N/A
Per T allele 0.56 (0.03–9.16) 0.686
rs34626614c GG 320 (100.0) 825 (100.0) 1.00
56103563 GA 0 (0.0) 0 (0.0) N/A N/A
AA 0 (0.0) 0 (0.0) N/A N/A
Per A allele N/A N/A
rs2569527 AA 317 (99.1) 817 (99.0) 1.00
56103448 AC 3 (0.9) 8 (1.0) 0.96 (0.25–3.65) 0.948
CC 0 (0.0) 0 (0.0) N/A N/A
Per C allele 0.96 (0.25–3.65) 0.948
rs189903c CC 299 (100.0) 762 (99.9) 1.00
56103377 CT 0 (0.0) 1 (0.1) N/A N/A
TT 0 (0.0) 0 (0.0) N/A N/A
Per T allele N/A N/A
rs2979451b AA 175 (53.2) 394 (47.1) 1.00
56103200 AG 127 (38.6) 368 (44.0) 1.24 (0.94–1.63) 0.122
GG 27 (8.2) 76 (9.0) 1.21 (0.75–1.95) 0.437
Per G allele 1.16 (0.94–1.42) 0.159
rs1701929b TT 180 (53.6) 460 (54.7) 1.00
56103141 TC 132 (39.3) 341 (40.5) 1.02 (0.78–1.33) 0.882
CC 24 (7.1) 40 (4.8) 0.62 (0.36–1.06) 0.080
Per C allele 0.90 (0.73–1.11) 0.334
rs7255024 CC 272 (87.7) 696 (88.3) 1.00
56103075 CA 36 (11.6) 91 (11.5) 1.00 (0.66–1.51) 0.996
AA 2 (0.6) 1 (0.1) 0.19 (0.02–2.15) 0.181
Per A allele 0.92 (0.62–1.35) 0.658
rs1654553* AA 87 (26.0) 226 (26.9) 1.00
56102928 AG 175 (52.2) 424 (50.5) 0.94 (0.69–1.28) 0.699
GG 73 (21.8) 189 (22.5) 1.03 (0.71–1.49) 0.868
Per G allele 1.01 (0.84–1.22) 0.895
rs2235091b TT 146 (43.5) 329 (39.1) 1.00
56102283 TC 145 (43.2) 387 (46.0) 1.15 (0.87–1.51) 0.325
CC 45 (13.4) 125 (14.9) 1.21 (0.82–1.80) 0.338
Per C allele 1.11 (0.93–1.34) 0.255
rs35945487 CC 312 (97.5) 806 (97.7) 1.00
56102098 CT 8 (2.5) 19 (2.3) 0.96 (0.41–2.23) 0.921
TT 0 (0.0) 0 (0.0) N/A N/A
Per T allele 0.96 (0.41–2.23) 0.921
rs73042387 GG 228 (75.7) 584 (74.9) 1.00
56101983 GA 64 (21.3) 187 (24.0) 1.13 (0.82–1.57) 0.452
AA 9 (3.0) 9 (1.2) 0.40 (0.15–1.02) 0.055
Per A allele 0.96 (0.72–1.26) 0.754
rs1139132 CC 126 (41.7) 326 (41.5) 1.00
56101575 CA 137 (45.4) 351 (44.7) 0.99 (0.74–1.32) 0.931
AA 39 (12.9) 109 (13.9) 1.05 (0.69–1.60) 0.818
Per A allele 1.01 (0.83–1.23) 0.883
rs1701927 AA 223 (69.7) 592 (71.8) 1.00
56100654 AC 88 (27.5) 218 (26.4) 0.93 (0.69–1.25) 0.622
CC 9 (2.8) 15 (1.8) 0.60 (0.26–1.41) 0.241
Per C allele 0.88 (0.68–1.13) 0.325
rs1701926 TT 217 (68.2) 568 (71.7) 1.00
56100570 TG 93 (29.2) 211 (26.6) 0.87 (0.65–1.17) 0.359
GG 8 (2.5) 13 (1.6) 0.60 (0.24–1.49) 0.272
Per G allele 0.85 (0.65–1.09) 0.198
rs2569530 GG 67 (23.8) 181 (26.2) 1.00
56100420 GT 148 (52.7) 352 (51.0) 0.87 (0.62–1.23) 0.438
TT 66 (23.5) 157 (22.8) 0.89 (0.59–1.33) 0.570
Per T allele 0.94 (0.77–1.15) 0.560
rs1090649 CC 217 (68.0) 567 (71.7) 1.00
56098343 CG 94 (29.5) 211 (26.7) 0.87 (0.65–1.16) 0.330
GG 8 (2.5) 13 (1.6) 0.60 (0.24–1.49) 0.273
Per G allele 0.84 (0.65–1.09) 0.183
rs11881354 AA 135 (43.1) 328 (40.6) 1.00
56097941 AG 139 (44.4) 368 (45.6) 1.05 (0.79–1.39) 0.726
GG 39 (12.5) 111 (13.8) 1.15 (0.75–1.74) 0.521
Per G allele 1.07 (0.88–1.29) 0.518
rs806019 CC 222 (69.4) 590 (71.5) 1.00
56097794 CG 89 (27.8) 220 (26.7) 0.93 (0.69–1.24) 0.618
GG 8 (2.8) 15 (1.8) 0.60 (0.26–1.41) 0.241
Per G allele 0.88 (0.68–1.13) 0.323
rs806020 GG 82 (26.3) 216 (26.8) 1.00
56097620 GA 164 (52.6) 402 (49.9) 0.94 (0.69–1.29) 0.692
AA 66 (21.2) 187 (23.2) 1.11 (0.76–1.63) 0.579
Per A allele 1.05 (0.87–1.27) 0.615
rs806021 AA 84 (26.8) 223 (27.7) 1.00
56097485 AG 164 (52.4) 397 (49.3) 0.91 (0.67–1.25) 0.564
GG 65 (20.8) 185 (23.0) 1.10 (0.75–1.61) 0.613
Per G allele 1.04 (0.86–1.26) 0.669
rs806022 GG 83 (26.0) 220 (26.7) 1.00
56096999 GT 165 (51.7) 417 (50.5) 0.95 (0.70–1.30) 0.763
TT 71 (22.3) 188 (22.8) 1.03 (0.71–1.50) 0.884
Per T allele 1.01 (0.84–1.22) 0.903
rs806023 AA 85 (26.7) 227 (27.6) 1.00
56096896 AG 164 (51.6) 409 (49.8) 0.93 (0.68–1.27) 0.639
GG 69 (21.7) 186 (22.6) 1.04 (0.71–1.51) 0.854
Per G allele 1.01 (0.84–1.22) 0.891
rs2569535 GG 315 (99.1) 821 (99.9) 1.00
56096639 GC 3 (0.9) 1 (0.1) 0.16 (0.02–1.56) 0.114
CC 0 (0.0) 0 (0.0) N/A N/A
Per C allele 0.16 (0.02–1.56) 0.114
rs1701941 TT 80 (25.1) 209 (25.4) 1.00
56096032 TA 163 (51.1) 418 (50.9) 0.97 (0.71–1.34) 0.872
AA 76 (23.8) 195 (23.7) 1.00 (0.69–1.45) 0.995
Per A allele 1.00 (0.83–1.20) 0.998
rs1654513 AA 132 (41.3) 367 (44.5) 1.00
56094494 AG 148 (46.3) 375 (45.5) 0.92 (0.70–1.21) 0.543
GG 40 (12.5) 83 (10.1) 0.75 (0.49–1.15) 0.189
Per G allele 0.88 (0.73–1.07) 0.208
rs8104538 TT 161 (50.3) 393 (47.7) 1.00
56093609 TC 126 (39.4) 345 (41.9) 1.11 (0.84–1.47) 0.450
CC 33 (10.3) 86 (10.4) 1.09 (0.70–1.70) 0.705
Per C allele 1.07 (0.88–1.30) 0.512
rs10409668c CC 320 (100.0) 824 (99.9) 1.00
56093213 CT 0 (0.0) 1 (0.1) N/A N/A
TT 0 (0.0) 0 (0.0) N/A N/A
Per T allele N/A N/A
rs1560719 TT 129 (41.1) 301 (37.4) 1.00
56092648 TC 137 (43.6) 383 (47.6) 1.18 (0.88–1.56) 0.269
CC 48 (15.3) 121 (15.0) 1.07 (0.72–1.59) 0.746
Per C allele 1.06 (0.88–1.29) 0.519
rs2739493 TT 112 (35.0) 276 (33.6) 1.00
56092488 TG 153 (47.8) 401 (48.8) 1.03 (0.77–1.37) 0.857
GG 55 (17.2) 145 (17.6) 1.04 (0.71–1.53) 0.832
Per G allele 1.02 (0.85–1.23) 0.819
rs1701934 GG 316 (98.8) 819 (99.3) 1.00
56092213 GA 4 (1.3) 6 (0.7) 0.66 (0.18–2.37) 0.521
AA 0 (0.0) 0 (0.0) N/A N/A
Per A allele 0.66 (0.18–2.37) 0.521
rs1560723 TT 316 (98.8) 818 (99.3) 1.00
56092168 TC 4 (1.3) 6 (0.7) 0.66 (0.18–2.37) 0.522
CC 0 (0.0) 0 (0.0) N/A N/A
Per C allele 0.66 (0.18–2.37) 0.522
rs1701936 CC 318 (99.4) 823 (99.9) 1.00
56091945 CT 2 (0.6) 1 (0.1) 0.28 (0.03–3.18) 0.307
TT 0 (0.0) 0 (0.0) N/A N/A
Per T allele 0.28 (0.03–3.18) 0.307
rs1654514 AA 316 (98.8) 819 (99.3) 1.00
56091856 AG 4 (1.3) 6 (0.7) 0.66 (0.18–2.37) 0.521
GG 0 (0.0) 0 (0.0) N/A N/A
Per G allele 0.66 (0.18–2.37) 0.521
rs1701937 CC 318 (99.4) 824 (99.9) 1.00
56091743 CA 2 (0.6) 1 (0.1) 0.28 (0.03–3.17) 0.306
AA 0 (0.0) 0 (0.0) N/A N/A
Per A allele 0.28 (0.03–3.17) 0.306

SNP, single nucleotide polymorphism; chr, chromosome; n, number; OR, odds ratio; CI, confidence interval.

a

Co-ordinates from hg18.

b

tagSNP;

c

SNP too infrequent in these groups to calculate OR (95% CI).

Bold, SNPs displaying a Ptrend value <0.05.