Table 2. Bacitracin MIC values (µg/mL) of C. perfringens strain c1261_A grown with different concentrations of efflux pump inhibitors.
Efflux pump inhibitor concentration (µg/mL) | |||||||||||||
0 | 1 | 2 | 4 | 8 | 16 | 32 | 64 | 128 | 256 | 512 | 1024 | 2048 | |
Efflux pump inhibitor(MIC, µg/mL) | Bacitracin MIC value (µg/mL) | ||||||||||||
MK-571 (64) | 512 | 512 | 512 | 512 | 512 | 256 | 128 | – | |||||
Thioridazine (16) | 512 | 512 | 256 | 256 | 8 | – | – | – | |||||
Prochlorperazine (64) | 512 | 512 | 512 | 512 | 512 | 512 | 256 | – | |||||
Verapamil (1024) | 512 | 512 | 512 | 512 | 512 | 512 | 512 | 512 | 512 | 256 | 128 | – | – |
Probenecid (1024) | 512 | 512 | 512 | 512 | 512 | 512 | 512 | 512 | 512 | 512 | 512 | – | – |
Reserpine (2048) | 512 | 512 | 512 | 512 | 512 | 512 | 512 | 512 | 512 | 512 | 512 | 256 | – |
Blank area, concentrations not tested; –, no bacterial growth due to efflux pump inhibitors.