Figure 3. Tumor growth patterns of mCherry-labeled tumor cells.

A. Size of U-87 MG (red, n = 3) and Clone #1 (black, n = 3) tumors measured by caliper (left panel) and by non-invasive CRI Maestro™ imaging system (right panel). B. Forty days post subcutaneous inoculation of mCherry-labeled U-87 MG and Clone #1 cells into SCID mice, U-87 MG cells established vascularized and palpable tumors (∼1200 mm³), whereas Clone #1 tumors remained avascular and non-palpable (left panel), but detectable by non-invasive CRI Maestro™ imaging system (right panel). C. Fiber confocal microscopy imaging of U-87 MG and Clone #1 tumor vasculature, as well as abdominal blood vessels, on day 40.