Table 4. The p-values associated with the comparison of the RA and CTR groups and NARAC-A and NARAC-C using the successful models derived from pathways under consideration.
| Pathway | RA vs. CTR | NARAC-A vs. NARAC-C | ||
| Fitness | Randomization-test | Fitness | Randomization-test | |
| Test Pathways | ||||
| Antigen Processing and Presentation | 8.17×10−17 | <10−5 | 1.47×10 −17 | <10−5 |
| B-cell Receptor Signaling | 8.31×10−18 | <10−5 | 4.54×10− 5 | >0.05 |
| Chemokine Signaling | 1.44×10−13 | <10−5 | 6.47×10−8 | 0.03463 |
| Complement and Coagulation Cascades | 3.11×10−28 | <10−5 | 7.17×10−25 | <10−5 |
| Cytokine-Cytokine Receptor Interaction | 5.51×10−30 | <10−5 | 6.34×10− 5 | >0.05 |
| Fc Epsilon RI Signaling | 2.73×10− 6 | >0.05 | 7.52×10− 7 | >0.05 |
| Fc Gamma R-mediated Phagocytosis | 9.09×10−10 | 3×10−4 | 5.65×10−17 | <10−5 |
| Intestinal Immune Network for IgA Production | 5.99×10−19 | <10−5 | 1.41×10−17 | <10−5 |
| Leukocyte Trans-endothelial Migration | 4.61×10−25 | <10−5 | 4.44×10−9 | 0.00310 |
| Natural Killer Cell Mediated Cytotoxicity | 7.37×10−13 | <10−5 | 5.15×10−9 | 0.00793 |
| Phagosome | 2.34×10−23 | <10−5 | 0.00532 | >0.05 |
| Regulation of Autophagy | 0.00172 | >0.05 | 9.99×10− 5 | >0.05 |
| T-cell Receptor Signaling | 2.90×10−10 | 2 ×10−5 | 5.85×10−15 | <10−5 |
| Toll-like Receptor Signaling | 2.96×10−18 | <10−5 | 1.96×10− 4 | >0.05 |
| Control Pathways | ||||
| Cardiac Muscle Contraction | 0.00405 | >0.05 | 4.44×10− 5 | >0.05 |
| Gap Junction | 7.72×10− 5 | 0.04995 | 0.01804 | >0.05 |
| Glycolysis/Gluconeogenesis | 0.00025 | >0.05 | 3.51×10− 5 | >0.05 |
| Insulin Signaling | 2.37×10− 6 | 0.00860 | 0.00186 | >0.05 |
| Nucleotide Excision Repair | 7.01×10− 5 | >0.05 | 0.01216 | >0.05 |
| Oxidative Phosphorylation | 1.72×10− 9 | 0.00460 | 2.77×10− 6 | >0.05 |
| Purine Metabolism | 0.04224 | >0.05 | >0.05 | >0.05 |
| Pyrimidine Metabolism | 0.00371 | >0.05 | 0.00034 | >0.05 |
| Renin Angiotensin System | 0.00216 | >0.05 | 0.00248 | >0.05 |
| Spliceosome | 1.09×10− 6 | 0.02772 | 5.78×10− 6 | >0.05 |
According to Bonferroni’s correction, a fitness p-value <6.944×10− 9 and a randomization test p-value <0.00208 were considered significant. The p-values of the models showing significant association with rheumatoid arthritis comparing RA vs. CTR are in bold. Of these 12 pathways, five were replicated in NARAC dataset at the significance level of 0.00208 and three were replicated at the significance level of 0.05. The p-values of these replicated models are also in bold.