Table 4. Genes annotated as “putative or unknown function” identified as contributing to cytosolic redox homeostasis in this study and their oxidative stress phenotype(s).
Gene | Phenotype | Reference |
DOG2 | Induced by oxidative stress | [20] |
DGR2 | Implicated in stress response signalling | [54] |
RPI1 | Inhibitor of Ras-cAMP pathway | [55] |
PMP3 | Increased glutathione excretion | [24] |
HMS2 | Predicted to regulated some responses to reducing conditions, heat shock and hydrogen peroxide.Homolog of SKN7 | [56] |
SVF1 | Inhibits reactive oxygen species generation and promotes cell survival under oxidative stress conditions | [57] |
ECM25 | Increased glutathione secretion; decreased oxidative stress resistance | [24], [58] |
ISF1 | Similar to Mbr1p, a protein involved in mitochondrial function and stress responses | [59] |