Skip to main content
. Author manuscript; available in PMC: 2013 Mar 1.
Published in final edited form as: Leukemia. 2012 Apr 27;26(9):2069–2078. doi: 10.1038/leu.2012.116

Table 1. Zebrafish T-ALL is molecularly similar to mouse and human disease.

Microarray gene expression signatures were identified by comparing zebrafish T-ALL to normal thymocytes. The up- and down-regulated gene sets were assessed for concordant gene regulation in human and mouse disease. The mouse T-ALL to thymocyte comparisons were made using GSE19499 and GSE7050 data sets, while human T-ALL to B-ALL comparisons were made using GSE13425. Similar results were observed using the human GSE13351 data set (data not shown). GSEA significance was defined by p-value <0.05 and a false-discovery rate of ≤0.25 (FDR) at three different fold cut-offs. Number of common probes found at each fold-change cut off (# of probes), Enrichment Score (ES), Normalized Enrichment Score (NES). Negative ES and NES scores indicate that the gene set is down regulated within the samples being compared.

GSEA Comparison Gene Set # of probes ES NES FDR p-value
Mouse T-ALL to thymocytes 2.5 fold Up 585 0.486 2.031 0.000 <0.001
Mouse T-ALL to thymocytes 3.0 fold Up 361 0.428 1.841 0.000 <0.001
Mouse T-ALL to thymocytes 3.5 fold Up 192 0.404 1.699 0.002 0.001

Mouse T-ALL to thymocytes 2.5 fold Down 532 −0.367 −1.770 0.000 <0.001
Mouse T-ALL to thymocytes 3.0 fold Down 348 −0.361 −1.584 0.009 0.004
Mouse T-ALL to thymocytes 3.5 fold Down 199 −0.385 −1.579 0.007 0.003

Human T-ALL to B-ALL 2.5 fold Up 534 0.465 2.077 0.000 <0.001
Human T-ALL to B-ALL 3.0 fold Up 312 0.468 2.001 0.000 <0.001
Human T-ALL to B-ALL 3.5 fold Up 156 0.442 1.773 0.000 <0.001

Human T-ALL to B-ALL 2.5 fold Down 517 −0.355 −1.637 0.000 <0.001
Human T-ALL to B-ALL 3.0 fold Down 328 −0.395 −1.752 0.000 <0.001
Human T-ALL to B-ALL 3.5 fold Down 209 −0.426 −1.799 0.000 <0.001