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. Author manuscript; available in PMC: 2013 Oct 11.
Published in final edited form as: Oncogene. 2012 Jun 4;32(15):1950–1958. doi: 10.1038/onc.2012.210

Figure 6. Sustained Mist1myc expression inhibits ADM and PanIN formation in vivo.

Figure 6

(A) PanIN formation (arrows) is greatly accelerated in KO/Kras pancreata but suppressed by sustained Mist1myc expression in KO/Kras/Mist1myc mice. Acinar-derived PanINs are Mist1 negative in HET/Kras mice. Interestingly, induced Mist1myc expression alone is not sufficient to inhibit all PanIN formation since some MIST1myc+ PanINs still develop in KO/Kras/Mist1myc pancreata. asterisks - adjacent acinar tissue. (B) Quantification of ADM and PanIN lesions in HET/Kras, KO/Kras and KO/Kras/Mist1myc samples. Note that constitutive Mist1myc leads to significant reductions in ADM/PanIN formation. (C) Analysis of gene expression profiles by RT-qPCR confirms the reduced ADM/PanIN formation in KO/Kras/Mist1myc samples when compared to KO/Kras littermates. All values were normalized to the control HET samples, which were set to 1.0.