Table 2.

Mean (± SD) metabolite levels (normalized to T2-corrected water signal intensity) and metabolite ratios for AD subjects at t₀, t₁, and t₂

	t0	t1	t2	t1 − t0	t2 − t1	[(t2 − t1) − (t1 − t0)]	p value1
NAA	651±68	678±94	651±81	27±41	−26±76	−54±102	0.240(n.s.)
Cr	452±45	452±48	450±63	0±13	−2±33	−2±36	0.831(n.s.)
Cho	285±31	282±32	289±39	−2±14	6±17	9±12	0.067(n.s.)
mI	280±48	277±49	289±57	−3±23	13±21	16±23	0.032
NAA/Cr	1.44±0.09	1.50±0.10	1.46±0.17	0.06±0.06	−0.04±0.14	−0.09±0.15	0.106(n.s.)
Cho/Cr	0.63±0.06	0.63±0.06	0.64±0.05	−0.01±0.03	0.02±0.04	0.02±0.06	0.246(n.s.)
mI/Cr	0.62±0.07	0.61±0.09	0.64±0.08	−0.01±0.05	0.03±0.04	0.04±0.08	0.142(n.s.)
NAA/Cho	2.30±0.29	2.42±0.37	2.28±0.26	0.11±0.17	−0.14±0.30	−0.26±0.39	0.083(n.s.)
NAA/mI	2.37±0.35	2.53±0.59	2.32±0.51	0.15±0.34	−0.20±0.31	−0.35±0.50	0.042

¹The Wilcoxon signed-rank test was used to examine whether the change between t0 and t1 differed from the change between t₁ and t₂ [(t₂ − t₁) − (t₁ − t₀)]. n.s. = Nonsignificant.