TABLE 4.

Postprandial changes in LDI and circulating measures of vascular function before (time 0) and 240 min following an oral fat load of either SFA or SFA + LC n-3 PUFA

	Females (mean ± SEM)		Males (mean ± SEM)		Differences between the Two Fat Loads
	Asp289 (n = 14)	Glu298 (n = 15)	Asp289 (n = 15)	Glu298 (n = 15)	P (genotype all)	P (gender all)
LDI AUC
LDI-Ach (AU) SFA fat load	596 ± 445	589 ± 347	524 ± 444	476 ± 460
LDI-Ach (AU)SFA + LC n-3 PUFA fat load	1296 ± 314*	309 ± 339	878 ± 437	569 ± 520	0.408	0.951
LDI-SNP (AU) SFA fat load	393 ± 424	626 ± 396	271 ± 578	926 ± 469
LDI-SNP (AU) SFA + LC n-3 PUFA fat load	1453 ± 347	719 ± 190	557 ± 659	393 ± 362	0.118	0.180
Circulating measures
ET-1 (ng/ml) SFA fat load	0.01 ± 0.01	−0.03 ± 0.05	−0.10 ± 0.09	0.04 ± 0.10
ET-1 (ng/ml) SFA +LC n3 PUFA fat load	−0.02 ± 0.08	0.01 ± 0.06	0.06 ± 0.05	0.02 ± 0.08	0.591	0.590
NOx (μM) SFA fat load	−4.73 ± 1.18	−3.01 ± 0.84	−2.29 ± 1.0	−4.59 ± 0.98
NOx (μM) SFA +LC n3 PUFA fat load	−2.89 ± 1.14	−3.86 ± 1.58	−2.35 ± 0.81	−2.37 ± 0.99	0.88	0.61

Statistical significance of difference between genotypes within a gender: *P ≤ 0.05.