. 2012 Jul;4(4):312–318. doi: 10.1177/1941738112446684

Table 3.

Comparative findings of associations with target single-nucleotide polymorphisms and joint laxity versus anterior cruciate ligament (ACL) injury.

Gene	Polymorphism	Associations With Laxity	Associations With ACL Injury
COL1A1	rs1800012	TG + TT genotypes were associated with greater GR vs the GG genotype (all subjects)	TT genotype was underrepresented in ACL injured vs controls^18,29
COL5A1	rs12722 rs13946	CC genotype showed decreased GR and GJL than the CT genotype, and the CT showed greater GR vs the TT in females only No association	CC genotype was underrepresented in ACL-injured females compared to controls³¹ No association with ACL injured³¹
COL12A1	rs240736 rs970547	CC genotype (n = 2) was associated with greater GJL vs the CT or TT genotypes in males AA genotype was associated with greater AKL vs the GA + GG genotypes in females only	No association with ACL injured³⁰ AA genotype was overrepresented in ACL-injured females and females with family history of ACL injury compared to GA + GG³⁰