Table 1.
Levels of evidence per subject: Pancreatic disorders, extrahepatic biliary tree, endoscopic ultrasonography-guided therapy
| Ia | Ib | IIa | IIb | III | IV | Total | |
| Solid pancreatic tumors | |||||||
| Diagnosis, differential diagnosis | 1 | 0 | 1 | 10 | 34 | 45 | 86 |
| EUS - FNA, TCB, echobrush | 0 | 4 | 1 | 28 | 48 | 11 | 92 |
| Staging | 2 | 0 | 0 | 17 | 30 | 18 | 67 |
| Neuroendocrine tumors | 0 | 0 | 0 | 4 | 28 | 15 | 47 |
| Molecular markers | 0 | 0 | 1 | 5 | 16 | 3 | 25 |
| Screening | 0 | 0 | 1 | 5 | 6 | 7 | 19 |
| Elastography, CH-EUS | 0 | 0 | 1 | 13 | 7 | 4 | 25 |
| Other | 0 | 1 | 1 | 7 | 37 | 11 | 57 |
| Total | 3 | 5 | 6 | 89 | 206 | 115 | 418 |
| Pancreatic cysts | |||||||
| Diagnosis, differential diagnosis | 0 | 0 | 0 | 2 | 26 | 31 | 59 |
| EUS-FNA, TCB, brushing | 1 | 0 | 1 | 10 | 17 | 2 | 31 |
| IPMN | 0 | 1 | 0 | 5 | 27 | 6 | 39 |
| Molecular markers | 0 | 0 | 0 | 7 | 3 | 0 | 10 |
| EUS follow-up, clinical outcome | 0 | 0 | 0 | 0 | 5 | 0 | 5 |
| Other | 0 | 0 | 0 | 6 | 13 | 2 | 21 |
| Total | 1 | 1 | 1 | 30 | 91 | 41 | 165 |
| Chronic pancreatitis | |||||||
| Diagnosis | 0 | 0 | 6 | 14 | 20 | 21 | 61 |
| Autoimmune pancreatitis | 0 | 0 | 0 | 2 | 7 | 2 | 11 |
| Other | 0 | 0 | 0 | 2 | 4 | 5 | 11 |
| Total | 0 | 0 | 6 | 18 | 31 | 28 | 83 |
| Acute pancreatitis | |||||||
| Diagnosis | 0 | 0 | 1 | 4 | 7 | 10 | 22 |
| CBD stones | 0 | 0 | 0 | 4 | 1 | 1 | 6 |
| Other | 0 | 2 | 1 | 2 | 5 | 2 | 12 |
| Total | 0 | 2 | 2 | 10 | 13 | 13 | 40 |
| Extrahepatic biliary tree | |||||||
| Diagnosis (in general) | 1 | 1 | 0 | 12 | 8 | 9 | 29 |
| CBD stones | 3 | 3 | 7 | 21 | 6 | 16 | 56 |
| Cholangio-Ca | 0 | 0 | 0 | 3 | 9 | 11 | 23 |
| Gallbladder | 0 | 0 | 0 | 6 | 18 | 4 | 28 |
| IDUS | 0 | 0 | 0 | 12 | 11 | 7 | 30 |
| Periampullary neoplasms | 0 | 0 | 0 | 7 | 19 | 5 | 31 |
| Other | 1 | 0 | 0 | 8 | 19 | 5 | 33 |
| Total | 5 | 4 | 7 | 69 | 90 | 57 | 230 |
| EUS-guided therapy | |||||||
| Fluid collection drainage, necrosectomy | 0 | 2 | 0 | 8 | 31 | 14 | 55 |
| Billiary duct drainage | 0 | 0 | 0 | 2 | 23 | 15 | 40 |
| EUS-CPN, CPB | 2 | 3 | 0 | 4 | 4 | 11 | 24 |
| Pancreatic tumor therapy | 0 | 1 | 0 | 6 | 9 | 6 | 22 |
| Pancreatic duct drainage | 0 | 0 | 0 | 0 | 4 | 1 | 5 |
| Other | 0 | 1 | 0 | 0 | 3 | 3 | 7 |
| Total | 2 | 7 | 0 | 20 | 74 | 50 | 153 |
EUS-FNA: Endoscopic ultrasound-fine needle aspiration; TCB: Trucut biopsy; CH-EUS: Contrast harmonic EUS; IPMN: Intraductal papillary mucinous neoplasm; CBD: Common bile duct; IDUS: Intraductal ultrasound; CPN: Celiac plexus neurolysis; CPB: Celiac plexus block.