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. 2012 Aug 28;18(32):4363–4370. doi: 10.3748/wjg.v18.i32.4363

Table 1.

Results of the gastroesophageal reflux disease impact scale questionnaire before and after proton pump inhibitor therapy

How often have you had the following symptoms: (GIS questionnaire) Before PPI therapy
After PPI therapy
P value
Always Often Sometimes Never Always Often Sometimes Never
Pain in your chest or behind the breastbone? 1 0 0 0 0 0 1 0 NS
Burning sensation in your chest or behind the breastbone? 10 4 1 0 3 1 1 10 < 0.05
Regurgitation or acid taste in your mouth? 2 5 2 0 1 1 3 4 < 0.05
Pain or burning in your upper stomach? 1 2 2 0 0 1 1 3 < 0.05
Sore throat or hoarseness that is related to your heartburn or acid reflux? 27 5 9 0 23 8 6 4 NS

NS: Not statistically significant; GIS: Gastroesophageal reflux disease impact scale; PPI: Proton pump inhibitor.