. 2011 Aug 16;133(35):14136–14148. doi: 10.1021/ja205884y

Table 2. Overview of Transport Assays and Lipophilicity of Compounds 1–10.

compound	clog P^a	k_ini^b (Cl^–/NO₃^–)	EC_{50, 270s}^c (Cl^–/NO₃^–)	n^d (Cl^–/NO₃^–)	k_ini^e (Cl^–/HCO₃^–)	EC_{50, 270s}^c (Cl^–/HCO₃^–)	n^d (Cl^–/HCO₃^–)
	Urea-Based Compounds
1	2.06	0.081	5.6	1.2	0.024	>5 ^f	–^f
2	2.53	0.571	0.43	1.4	0.081	>5 ^f	–^f
3	4.43	1.84	0.24	1.4	0.250	–^g	–^g
4	4.82	1.35	0.052	1.1	0.46	0.24	1.2
5	7.59	1.01	0.0044	1.6	0.77	0.036	1.5
	Thiourea-Based Compounds
6	5.50	0.97	0.31	1.9	0.186	2.3	1.0
7	5.97	3.3	0.042	2.9	0.47	0.35	1.2
8	7.87	3.2	0.032	2.4	0.38	–^g	–^g
9	8.26	1.18	0.077	4.8	0.47	0.11	4.8
10	11.03	0.90	0.042	5.0	0.76	0.14	3.8

clog P calculated using Spartan ’08 for Macintosh (Ghose–Crippen model).

Initial rate of chloride efflux for 2% molar carrier to lipid (% s^–1).

EC_{50, 270s} defined as concentration (mol % carrier to lipid) needed to obtain 50% efflux after 270 s.

Hill coefficient.

Initial rate of chloride efflux (after addition of NaHCO₃) for 2% carrier to lipid (% s^–1).

Accurate Hill analysis could not be performed due to low activity.

Meaningful Hill analysis could not be performed due to significant background transport in the absence of NaHCO₃ (HCl symport and/or Cl^–/SO₄^2– antiport).