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. 2012 Oct 1;139(19):3653–3664. doi: 10.1242/dev.078592

Fig. 1.

Fig. 1.

Knockout of mouse Kir2.1 causes cleft of the secondary palate and patterning defects of the skeletal digits. (A-D) Ventral view of Alizarin Red (bone) staining of palates of newborn wild-type (A), Kir2.1 knockout (B) and Kir2.1 heterozygous knockout (C,D) pups. (E,F) Ventral view of wild-type palate (E) and Kir2.1 knockout cleft of secondary palate (F). (G,H) Forelimb of wild-type (G) and Kir2.1 knockout (H). (I,J) Ventral view of a wild-type (I) and Kir2.1 knockout (J) forepaw. (K,L) Whole-mount forelimb skeletons from newborn animals stained with Alcian Blue and Alizarin Red: wild-type (K); preaxial digit duplication of the forelimb is shown in the Kir2.1 knockout (L). The dorsal view of the right limb is shown. Anterior is upwards.

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