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. Author manuscript; available in PMC: 2013 Sep 1.
Published in final edited form as: Free Radic Biol Med. 2012 Jul 13;53(5):1048–1060. doi: 10.1016/j.freeradbiomed.2012.07.004

Figure 1. Synaptic gene expression levels in Sod2 −/− animals and wild-type mice reveal expression changes related to the level of oxidative stress.

Figure 1

Heatmap of significant changes in genome expression changes reveal that the expression changes in the mice are most apparent in the animals that are treated with a low dose of EUK-189 synthetic antioxidant. Gene expression upregulation is colored in red/yellow, while downregulated genes are shown in blue/green. Using hierarchical clustering of each animal based upon these changes results in 8 of 10 low dose Sod2 −/− mice (KO_L, Red) to cluster into branch A. This expression of the transcriptome shifts to a pattern more akin to wild-type animals (WT_L and WT_H, Light Blue and Dark Blue) with the administration of a high dose of EUK-189 in the Sod2 −/− mice (KO_H, Yellow) and clusters among them in branches B and C.