Figure 7. Correlation of the proteomic and gene expression analysis.

To examine the correlation between the expression changes at the gene expression level to the protein levels detected with mass spectrometry we have expressed this data as a chart displaying the ratio between the wild-type and Sod2 −/− synaptosome samples. This chart identifies that some proteins levels do correlate with the gene expression data, while others do not match their gene expression levels. This reveals that the gene expression and protein level does not necessarily correlate which suggests that a multilevel approach to examination of a disease state is potentially more powerful then examining gene expression or proteins alone.