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. 2012 Jul 3;287(35):29672–29678. doi: 10.1074/jbc.M111.322404

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© 2012 by The American Society for Biochemistry and Molecular Biology, Inc.

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FIGURE 5. — Model depicting the role of p62 in insulin signaling. p62 interacts with IRS-1 on insulin stimulation and leads to Akt activation, GLUT4 translocation, and glucose uptake. Effect of p62 on Akt phosphorylation (indicated by circled P) may involve other proteins such as TRAF6 (35, 38).