TABLE 2.
List of deregulated genes involved in cell division and DNA replication
Genes down-regulated at least 1.5-fold upon loss of Ada3 as obtained from microarray analyses. The genes were classified based upon gene ontology biological processes.
| Gene symbol | Gene title | -Fold down-regulated |
|---|---|---|
| Genes involved in cell division | ||
| Kifc1 | Kinesin family member C1, similar to Kifc1 protein | 2.0 |
| Nfkbil1 | Nuclear factor of [kappa[ light polypeptide gene enhancer in B-cells inhibitor-like 1 | 2.0 |
| Fbxo5 | F-box protein 5 | 1.8 |
| Cenpf | Centromere protein F | 1.8 |
| Cdc6 | Cell division cycle 6 homolog (Saccharomyces cerevisiae) | 1.7 |
| Kntc1 | Kinetochore-associated 1 | 1.7 |
| Baz1b | Bromodomain adjacent to zinc finger domain, 1B | 1.6 |
| Mlf1ip | Myeloid leukemia factor 1 interacting protein | 1.6 |
| Myh10 | Myosin, heavy polypeptide 10, non-muscle | 1.6 |
| Kif11 | Kinesin family member 11 | 1.6 |
| Ccna2 | Cyclin A2 | 1.6 |
| Smc2 | Structural maintenance of chromosomes 2 | 1.6 |
| Plk1 | Polo-like kinase 1 (Drosophila) | 1.5 |
| Bub1b | Budding uninhibited by benzimidazoles 1 homolog, β (S. cerevisiae) | 1.5 |
| Aspm | asp (abnormal spindle)-like, microcephaly-associated (Drosophila) | 1.5 |
| Anln | Anillin, actin-binding protein | 1.5 |
| Zwilch | Zwilch, kinetochore-associated, homolog (Drosophila) | 1.5 |
| Mki67 | Antigen identified by monoclonal antibody Ki 67 | 1.5 |
| Mad2l1 | MAD2 mitotic arrest deficient-like 1 (yeast) | 1.5 |
| Smc4 | Structural maintenance of chromosomes 4 | 1.5 |
| Cdca8 | Cell division cycle-associated 8 | 1.5 |
| Kif20b | Kinesin family member 20B | 1.5 |
| Hells | Helicase, lymphoid-specific | 1.5 |
| Ccnb1 | Cyclin B1 | 1.5 |
| Cdca3 | Cell division cycle-associated 3 | 1.5 |
| Nuf2 | NUF2, NDC80 kinetochore complex component, homolog (S. cerevisiae) | 1.5 |
| Ndc80 | NDC80 homolog, kinetochore complex component (S. cerevisiae) | 1.5 |
| Birc5 | Baculoviral IAP repeat-containing 5 | 1.5 |
| Bub1 | Budding uninhibited by benzimidazoles 1 homolog (S. cerevisiae) | 1.5 |
| Suv39h2 | Suppressor of variegation 3–9 homolog 2 (Drosophila) | 1.5 |
| Aurkb | Aurora kinase B | 1.5 |
| Wee1 | WEE 1 homolog 1 (Schizosaccharomyces pombe) | 1.5 |
| Genes involved in DNA replication | ||
| Kitl | Kit ligand | 1.9 |
| Prim1 | DNA primase, p49 subunit | 1.7 |
| Mcm7 | Minichromosome maintenance-deficient 7 (S. cerevisiae) | 1.7 |
| Ccne2 | Cyclin E2 | 1.7 |
| Pola1 | Polymerase (DNA directed), alpha 1 | 1.7 |
| Dtl | Denticleless homolog (Drosophila) | 1.7 |
| Cdc6 | Cell division cycle 6 homolog (S. cerevisiae) | 1.7 |
| Chtf18 | CTF18, chromosome transmission fidelity factor 18 homolog (S. cerevisiae) | 1.7 |
| Nfib | nuclear factor I/B | 1.6 |
| Prim1 | DNA primase, p49 subunit | 1.6 |
| Orc1l | Origin recognition complex, subunit 1-like (S. cerevisiae) | 1.6 |
| Rrm1 | Ribonucleotide reductase M1 | 1.6 |
| Rpa1 | Replication protein A1 | 1.6 |
| Cdt1 | Chromatin licensing and DNA replication factor 1 | 1.6 |
| Gins2 | GINS complex subunit 2 (Psf2 homolog) | 1.5 |
| Rbbp4 | Retinoblastoma-binding protein 4 | 1.5 |
| Chaf1b | Chromatin assembly factor 1, subunit B (p60) | 1.5 |
| Tk1 | Thymidine kinase 1 | 1.5 |