FIGURE 8.

Proposed mechanism of CSR signaling in salivary duct. Diagram shows the proposed mechanism of CSR-regulated signaling in salivary ductal cells. The alteration in [Ca²⁺] in ductal lumen activates CSR, which in turn trigger TRPC3 activation though a PLC-dependent mechanism and causes Ca²⁺ entry into the ductal cell. This process could potentially initiate a transductal flow of Ca²⁺ from apical to basal end. Furthermore, Ca²⁺-sensing properties of CSR by [Ca²⁺]_o could potentially be modulated by the presence of endogenous (saliva) CSR modulator(s).