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. 2012 Jul 18;287(36):30406–30413. doi: 10.1074/jbc.M112.387464

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© 2012 by The American Society for Biochemistry and Molecular Biology, Inc.

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FIGURE 6. — Septin pairwise interactions are G interface-dependent. A, combinatorial septin pairwise interactions using SEPT2, SEPT6, and SEPT7. Cell lysates were immunoprecipitated (IP) with GFP antibody and immunoblotted with FLAG antibody. B, septin pairwise interaction of SEPT9_i3 with SEPT2, SEPT6, or SEPT7. Lanes marked G represent G mutants and correspond to W260A for SEPT2, W258A for SEPT6, and W249A for SEPT7. C, proposed model for septin complex assembly and filament formation. SEPT2 Δ15 filaments are made from initial G interface dimers that then interact at their NC interfaces. D, heterotypic septin filaments are composed of septin octamers that likely assemble through the strongest G dimer pairs.