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Revised scheme for prothrombin activation by prothrombinase. The individual half-reactions of prothrombin activation are separated by the slow and reversible equilibration of the intermediate, meizothrombin, between zymogen-like (mIIa′) and proteinase-like (mIIa) states. Steady state kinetic constants listed correspond to those determined for the action of prothrombinase on IIQ271 or mIIa covalently inactivated with FPRck (18).
