Table I.
Frequency of molecular alterations for each histological type observed in the human series.
| Variables | Normal | HYP | DYS | CIS | HGP | INV | p-value |
|---|---|---|---|---|---|---|---|
| n=27 | n=9 | n=2 | n=11 | n=19 | n=30 | ||
| n (%) | n (%) | n (%) | n (%) | n (%) | n (%) | ||
| DNA ploidy | <0.001 | ||||||
| Diploid | 26 (96.3) | 7 (77.8) | 1 (50) | 1 (9.1) | 7 (36.8) | 2 (6.7) | |
| Aneuploid | 1 (3.7) | 2 (22.2) | 1 (50) | 10 (90.9) | 12 (63.2) | 28 (93.3) | |
| 5cER | <0.001 | ||||||
| Without | 26 (96.3) | 7 (77.8) | 1 (50) | 1 (9.1) | 9 (47.4) | 2 (6.7) | |
| With | 1 (3.7) | 2 (22.2) | 1 (50) | 10 (90.9) | 10 (52.6) | 28 (93.3) | |
| p53 | 0.001 | ||||||
| Negative | 26 (96.3) | 8 (88.9) | 1 (50) | 7 (63.6) | 14 (73.7) | 15 (50.0) | |
| Positive | 1 (3.7) | 1 (11.1) | 1 (50) | 4 (36.4) | 5 (26.3) | 15 (50.0) | |
| Ki-67 | <0.001 | ||||||
| Negative | 26 (96.3) | 9 (100) | 2 (100) | 4 (36.4) | 7 (36.8) | 8 (26.7) | |
| Positive | 1 (3.7) | 0 (0) | 0 (0) | 7 (63.6) | 12 (63.2) | 22 (73.3) |
Normal, morphological normal urothelium; HYP, hyperplasia; DYS, dysplasia; CIS, carcinoma in situ; HGP, high-grade papillary urothelial carcinoma; INV, invasive urothelial carcinoma.