Table II.
Incidence of urothelial histopathological lesions in rats exposed to N-butyl-N-(4-hydroxybutyl)-nitrosamine and treated with Mitomycin C and physiological saline solution.
| Group (n) | Normal | HYP | DYS | CIS | LGP | HGP | INV |
|---|---|---|---|---|---|---|---|
| n=10 | n=6 | n=41 | n=7 | n=40 | n=30 | n=10 | |
| n (%) | n (%) | n (%) | n (%) | n (%) | n (%) | n (%) | |
| 1 (10) | 10 (100) | 0 (0.0) | 0 (0.0) | 0 (0) | 0 (0.0) | 0 (0.0) | 0 (0.0) |
| 2 (12) | 0 (0) | 2 (16.6) | 10 (87.3) | 0 (0) | 10 (83.3) | 2 (16.6) | 2 (16.6) |
| 3 (10) | 0 (0) | 2 (20.0) | 10 (100.0) | 0 (0) | 10 (100.0) | 9 (90.0) | 1 (10.0) |
| 4 (11) | 0 (0) | 1 (9.0) | 11 (100.0) | 0 (0) | 11 (100.0) | 11 (100.0) | 5 (45.4) |
| 5 (10) | 0 (0) | 1 (10.0) | 10 (100.0) | 7 (70) | 9 (90.0) | 8 (80.0) | 2 (20.0) |
Normal, morphological normal urothelium; HYP, hyperplasia; DYS, dysplasia; CIS, carcinoma in situ; LGP, low-grade papillary urothelial carcinoma; HGP, high-grade papillary urothelial carcinoma; INV, invasive urothelial carcinoma.