Table III.
Frequency of molecular alterations for each histological type observed in the rat series.
| Variables | Normal | HYP | DYS | CIS | LGP | HGP | INV | p-value |
|---|---|---|---|---|---|---|---|---|
| n (%) | n (%) | n (%) | n (%) | n (%) | n (%) | n (%) | ||
| DNA ploidy | <0.001 | |||||||
| Diploid | 10 (100.0) | 4 (80.0) | 9 (56.3) | 0 (0.0) | 17 (70.8) | 0 (0.0) | 0 (0.0) | |
| Aneuploid | 0 (0.0) | 1 (20.0) | 7 (43.8) | 7 (100.0) | 7 (29.2) | 23 (100.0) | 3 (100.0) | |
| 5cER | <0.001 | |||||||
| Without | 8 (80.0) | 4 (80.0) | 9 (56.3) | 0 (0.0) | 19 (79.2) | 2 (8.7) | 0 (0.0) | |
| With | 2 (20.0) | 1 (20.0) | 7 (43.8) | 7 (100.0) | 5 (20.8) | 21 (91.3) | 3 (100.0) | |
| p53 (positivity) | ||||||||
| mean value | 10 (0.0) | 6 (20.7) | 17 (35.5) | 7 (37.4) | 34 (36.0) | 26 (44.0) | 4 (38.9) | <0.001 |
| Ki-67 (positivity) | ||||||||
| mean value | 10 (0.0) | 6 (16.8) | 17 (23.5) | 7 (29.3) | 34 (23.3) | 26 (34.0) | 4 (23.9) | <0.001 |
Normal, morphological normal urothelium; HYP, hyperplasia; DYS, dysplasia; CIS, carcinoma in situ; LGP, low-grade papillary urothelial carcinoma; HGP, high-grade papillary urothelial carcinoma; INV, invasive urothelial carcinoma.