Table I.
Respective correlation of VEGFR-3/Flt-4 and marked vascular density (MVD) with clinicopathological factors, VEGF-C and VEGF-D in early-stage cervical cancer tissues.
| Clinicopathological factors | n | VEGFR-3/Flt-4 | MVD [mean (SD)] | P-value | ||
|---|---|---|---|---|---|---|
|
|
||||||
| (+) | (−) | P-value | ||||
| Menstrual status | ||||||
| Pre-menopausal | 29 | 19 | 10 | NS | 25.97 (1.48) | NS |
| Menopausal | 12 | 7 | 5 | 25.41 (1.83) | ||
| Clinical stages | ||||||
| Ia | 7 | 3 | 4 | <0.01 | 23.29 (0.49) | <0.01 |
| Ib | 14 | 5 | 9 | 25.21 (0.43) | ||
| IIa | 20 | 18 | 2 | 27.10 (0.85) | ||
| Histological grade | ||||||
| G1 | 7 | 4 | 3 | NS | 25.43 (1.98) | NS |
| G2 | 13 | 8 | 5 | 26.08 (1.75) | ||
| G3 | 21 | 12 | 9 | 25.76 (1.37) | ||
| Lymph node metastasis | ||||||
| No | 26 | 12 | 14 | <0.05 | 25.50 (1.84) | NS |
| Yes | 15 | 14 | 1 | 26.33 (0.82) | ||
| Lymphatic invasion | ||||||
| No | 35 | 20 | 15 | <0.05 | 25.69 (1.66) | NS |
| Yes | 6 | 6 | 0 | 26.50 (0.84) | ||
| Histological classification | ||||||
| Squamous cell carcinoma | 37 | 23 | 14 | NS | 25.78 (1.64) | NS |
| Adenocarcinoma | 4 | 3 | 1 | 26.00 (1.15) | ||
| VEGF-C | ||||||
| (+) | 20 | 17 | 3 | <0.01 | 24.50 (1.00) | <0.01 |
| (−) | 21 | 9 | 12 | 27.05 (0.86) | ||
| VEGF-D | ||||||
| (+) | 24 | 20 | 4 | <0.01 | 25.08 (1.38) | <0.01 |
| (−) | 17 | 6 | 11 | 26.82 (1.28) | ||
NS, no statistical significance.