Figure 1.

The effects of different modes of calorie restriction on mammary tumor development in MMTV-TGF-α mice euthanized at different ages. (A) Age of mammary tumor detection in ad libitum-fed (AL), intermittent calorie-restricted (ICR) and chronic calorie-restricted (CCR) mice with incidence rates. (B) Overall mammary tumor incidence for all mice. There were significant differences among the groups (P=0.0005). (C) Tumor grade for mammary tumors. The numbers in parenthesis are the number of mice that developed mammary tumors/total number of the mice.