Table I.
Genotype frequencies of polymorphic variants of CYP1A1 and GSTM1, and the smoking habits in oral cancer patients and control subjects in a sample of Chilean individuals.
| Genotypic variant | Control | Cancer | OR | 95% CI | P-value | ||
|---|---|---|---|---|---|---|---|
|
|
|
||||||
| n | % | n | % | ||||
| CYP1A1 | |||||||
| wt/wt | 75 | 60.48 | 22 | 45.83 | 1.00 | ||
| wt/m1 | 36 | 29.03 | 22 | 45.83 | 2.08 | 1.00–4.29 | 0.0422 |
| m1/m1 | 13 | 10.48 | 4 | 8.33 | 1.04 | 0.30–3.56 | 0.9389 |
| Allelic variant | |||||||
| wt | 186 | 75.00 | 66 | 68.70 | 1.00 | ||
| m1 | 62 | 25.00 | 30 | 31.30 | 1.36 | 0.77–2.35 | 0.2401 |
| GSTM1 | |||||||
| Positive | 100 | 80.65 | 24 | 50.00 | 1.00 | ||
| Null | 24 | 19.35 | 24 | 50.00 | 4.16 | 1.95–8.89 | 0.0001 |
| Smoking | |||||||
| No | 60 | 48.39 | 7 | 14.58 | 1.00 | ||
| Yes | 64 | 51.61 | 41 | 85.42 | 5.49 | 2.17–13.83 | <0.0001 |
OR, odds ratio; CI, confidence interval; wt, wild-type.