Table II.
Joint effect of genotypic polymorphic variants of CYP1A1 and GSTM1 and smoking in oral cancer patients and control subjects in a sample of Chilean individuals (adjusted by age and gender).
| Smoking | Genotypic variant | Cancer | Control | OR | 95% CI | P-value | ||
|---|---|---|---|---|---|---|---|---|
|
|
|
|||||||
| n | % | n | % | |||||
| CYP1A1 | ||||||||
| − | wt/wt | 4 | 8.33 | 35 | 28.23 | 1.00 | ||
| − | wt/m1 | 3 | 6.25 | 15 | 12.10 | 1.51 | 0.27–8.23 | 0.6310 |
| − | m1/m1 | 0 | 0.00 | 10 | 8.06 | 0.00 | -- | 0.2956 |
| + | wt/wt | 18 | 37.50 | 40 | 32.26 | 3.89 | 1.08–13.98 | 0.0370 |
| + | wt/m1 | 19 | 39.58 | 21 | 16.94 | 5.68 | 1.57–20.44 | 0.0080 |
| + | m1/m1 | 4 | 8.33 | 3 | 2.42 | 7.77 | 1.07–55.91 | 0.0420 |
| GSTM1 | ||||||||
| − | positive | 4 | 8.33 | 48 | 38.71 | 1.00 | ||
| − | null | 3 | 6.25 | 12 | 9.68 | 2.75 | 0.48–15.79 | 0.1730 |
| + | positive | 20 | 41.67 | 52 | 41.94 | 3.57 | 1.05–12.09 | 0.0410 |
| + | null | 21 | 43.75 | 12 | 9.68 | 20.81 | 5.45–79.34 | <0.0001 |
| CYP1A1/GSTM1a | ||||||||
| − | wt/wt/positive | 2 | 4.17 | 32 | 25.81 | 1.00 | ||
| + | wt/m1/null | 7 | 14.58 | 5 | 4.03 | 19.14 | 2.82–129.95 | 0.0030 |
| + | m1/m1/null | 4 | 8.33 | 2 | 1.61 | 21.39 | 1.92–237.68 | 0.0130 |
OR, odds ratio; CI, confidence interval; wt, wild-type.
a
Some combinations were not analysed because no subjects were included or were physiologically relevant.