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IC50 (μM) of compounds 8 and 9 using the MTT assay (a 72-h continuous exposure).
| Cell Line | Cisplatin | 8a | 8b | 9a | 9b |
|---|---|---|---|---|---|
| B16 | 7.33 | >20 | 4.30 | 4.05 | 1.65 |
| BRO | 5.66 | >20 | 3.88 | 4.38 | 3.65 |
| HL-60 | 1.66 | >20 | 3.40 | 3.90 | 3.95 |
| MCF-7 | 15.99 | >20 | 4.35 | 4.85 | 4.36 |
| OVCAR 3 | 3.99 | >20 | 4.19 | 3.00 | 1.85 |
| P388/0 | - | >20 | 4.35 | 4.51 | 4.38 |
| PC 3 | 1.66 | >20 | 3.98 | 4.14 | 3.49 |
| HT-29 | 15.99 | >20 | 3.80 | 4.14 | 3.20 |
