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. 2012 Jul 2;287(34):29159–29167. doi: 10.1074/jbc.M112.365049

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© 2012 by The American Society for Biochemistry and Molecular Biology, Inc.

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FIGURE 5. — Osteoblast-specific deletion of OTRs recapitulates global OTR deficiency. The skeletons of 16-week-old osteoblast-specific Col2.3-Cre⁺/OTR^fl/fl mice or control Col2.3-Cre⁻/OTR^fl/fl littermates were phenotyped for differences in static and dynamic histomorphometry parameters. Representative images show von Kossa-stained trabecular bone (A) and micro-computed tomography of trabecular bone (B). C, micro-computed tomography (Micro-CT)-derived estimates of volumetric BMD, BV/TV, Tb.N, trabecular thickness (TbTh), trabecular spacing (TbSp), and connectivity density (Conn.D) in the two genotypes (units as shown). D, areal BMD (aBMD) using PIXImus of the osteoclast-specific TRAP-Cre⁺/OTR^fl/fl mice or control TRAP-Cre⁻/OTR^fl/fl littermates recorded at the stated sites. Statistics were as follows: Student's t test with the Bonferroni correction, comparing Col2.3-Cre⁺/OTR^fl/fl versus Col2.3-Cre⁻/OTR^fl/fl mice (C) (p values as shown) and TRAP-Cre⁺/OTR^fl/fl versus TRAP-Cre⁻/OTR^fl/fl mice (D). L, left; R, right.