TABLE 2.

Selected up- and down-regulated genes in the siOGA clone categorized according to cellular function

Genes names in boldface indicate that the protein is modified by O-GlcNAc (based on previous data).

Function	Up-regulated genes	Down-regulated genes
Growth factors and insulin signaling	IGF2, IGFBP5, IGFBP4, INS-IGF2, IGFBPL1, FGFR1, FGFR4, FGF13, CPE, TGFBR2, TGFBR3	IGF2BP3, FGFR1OP, FGFBP1, FGF9, TGFBI, TGFA
Transcription	JUN, PRDX4, PIAS3, UXT, SREBF2, MED14, BCOR, TFDP1, TCF19, BACH1, CREB3L2	T, TP53, TP53BP1, WWTR1, NFKBIB, TBP, GTF2F2, TCF25, USF2, CNOT3, CNOT1, HSF1, GTF3A, ELF1, HSF2, JDP2, PIAS1, TAF1, BRMS1, TAF5L, GTF2IRD1
Cell growth, differentiation, and proliferation	CCNG2, CDK2, CDK5, CDKAL1, CDCA4, CDCA7, GDF11, PDCD6IP, PLCG1, TMSL2, PROM1, RPS6KA3, S100A2, S100A3, S100A16, GADD45A	CDK10, CCND1, GAS6, AKT1S1, ITPKB, CDCA7L, TPD52L1, RB1
Cell-cell interaction and motility	GABRA2, TNC, LPXN, PCDHB5, FERMT2, CD24, SERPINE2, MCAM, ACTG1, DST, MYO10, KRT81, CDH1, CD99L2, ITGB7, ITGA2, CLDN1, CLDN12, CD302, FBLN1, LIMS3, ABLIM1, ABLIM3, FLNA, FLNB, TSPAN4, TSPAN12, ITGB5, EPHA4, EPHB6, EPHB3, THBS1, TUBA1A, TUBA4A, VSIG1, RAP2A, S100A6, FN1, LAMB1, L1CAM, TIMP1, VIM, TIMP2, CYFIP2, CEACAM1, EFNB2, AHNAK2, FSCN1	CLDN7, MMP14, PLAU, ADAMTS17, ADAM19, ADRM1, CELSR1, ST14, EFNB1, TIMP3, THSD1, ARPC4, ACTN4, KRT6C
Cell signaling	TSPAN5, ERBB3, ARAF, BRAF, ELK1, GEFT, MAP3K3, RASA3, FZD10, ICK, HIPK2, JAK1, CTNNB1, CTNNBIP1, KREMEN1, MAMLD1, CAV1, PAK1, RHOB, LRP1, LRP4, PLCG1, DAB2, LRIG1	FZD6, WNT11, SFRP5, CDCA7L, CAPN1, RAB27A
Cell death	CYFIP2, CASP2, CMTM8, PDCD6IP, SERPINB9	AIFM1, AIFM2, CIAPIN1, BCL2L13, BCL2L1, BNIP2, PDCD2, AVEN, TRADD, NOTCH2
Metabolism and biosynthesis	PDK1, G6PD, PHKA2, PDHA1, GK, TGDS, LIPC, STARD4, PLA2G16, SC4MOL, AZGP1, GLUL, ALDOC, FBP1, NSDHL, ANGPTL2, DHCR7, LSS, FDPS, FDFT1, PECR, ACSS2, PPAP2B, HMGCR, HMGCS1	GNE, GPT2, PFKM, PRKAR1B, PHKB, GALK2
Immune response	IL6R, IL8, IL17RD, IL23A, CXCL6, SLAMF9, IFNGR2	SIGIRR, IL20RA, CXCR3, IGBP1, HIVEP2