Dicer-dependent, HIF-independent down-regulation of VEGFA in chronic hypoxia.
A, VEGFA mRNA levels in control versus 24-h hypoxic Dicer-overexpressing and control vector-transfected HUVEC. Data represent mean ± S.E. (error bars) (n = 3). * and † denote p < 0.05 compared with control-empty vector and hypoxia-empty vector, respectively. B, relative firefly luciferase activity. Data represent mean ± S.E. (error bars) (n = 3). * and † denote p < 0.05 compared with control and hypoxic non-over-expressing HUVEC, respectively, with pLuc-VEGFA-3′-UTR.