Table 5.
Effects ofin ovoleptin administration on hepatic expression of miRNAs predicted to targetSREBP-1candHMGCRin newly hatched chicks
| Target Genes | miRNA | Control | Leptin | P value |
|---|---|---|---|---|
|
SREBP-1c |
gga-miR-99a |
0.98 ± 0.11 |
2.11 ± 0.42 |
0.024 |
| gga-miR-100 |
1.00 ± 0.11 |
2.03 ± 0.38 |
0.026 |
|
| gga-miR-183 |
1.05 ± 0.23 |
1.70 ± 0.23 |
0.070 |
|
| gga-miR-200b |
0.97 ± 0.11 |
1.99 ± 0.40 |
0.033 |
|
| gga-miR-429 |
1.05 ± 0.08 |
2.04 ± 0.40 |
0.038 |
|
|
HMGCR |
gga-miR-15a |
1.02 ± 0.12 |
1.84 ± 0.41 |
0.086 |
| gga-miR-15b |
1.00 ± 0.10 |
1.24 ± 0.27 |
0.427 |
|
| gga-miR-16 |
1.03 ± 0.11 |
1.62 ± 0.36 |
0.147 |
|
| gga-miR-27b |
1.02 ± 0.08 |
1.22 ± 0.23 |
0.416 |
|
| gga-miR-181a |
0.96 ± 0.08 |
1.00 ± 0.18 |
0.663 |
|
| gga-miR-200a |
1.02 ± 0.11 |
2.52 ± 0.64 |
0.045 |
|
| gga-miR-200b |
0.97 ± 0.11 |
1.99 ± 0.40 |
0.033 |
|
| gga-miR-223 |
1.04 ± 0.07 |
1.39 ± 0.28 |
0.249 |
|
| gga-miR-429 | 1.05 ± 0.08 | 2.04 ± 0.40 | 0.038 |
Values are presented as fold change relative to the control, expressed as means ± SEM (n = 12).