Table 1.
Year, Age, Sex | Past Medical History | Total Days of Daptomycin Exposure | Species | Source | Reason for Admission and/or Complications |
---|---|---|---|---|---|
2011 |
|
|
|
|
|
55F |
MDS, SCT |
5 |
E. faecium |
Blood, urine |
Neutropenia, GVHD of gut |
55F |
ALL, BMT, DM, PVD |
No |
E. faecium |
Blood |
Neutropenia, CDI |
58F |
Gynecological malignancy |
9 |
E. faecium |
Blood |
GI inflammation due to metastatic disease |
59F |
AML |
19 |
E. faecium |
Blood |
Neutropenia, appendicitis |
51F |
AML, SCT |
29 |
E. faecium |
Urinea |
Neutropenia, colitis |
2010 |
|
|
|
|
|
74F |
MDS, SBO, CHF, Pulmonary Htn |
10 |
E. faecium |
Urinea |
Small bowel resection, sepsis |
80F |
CAD, COPD, PVD |
No |
E. faecalis |
Urinea |
Bowel ischemia after surgery |
42 M |
DM, bipolar disorder |
12 |
E. faecium |
Wound, lumbar |
Chronic lumbar abscess |
56F |
AML, SCT, DM |
67 |
E. faecium |
Blood |
Neutropenia, sigmoid colon perforation |
2009 |
|
|
|
|
|
50F |
AML, SCT |
20 |
E. faecium |
Urinea |
Neutropenia, GVHD of gut, colitis |
50 M |
DM, Hip SSTI/osteomyelitis |
19 |
E. faecium |
Wound, hip |
Hip SSTI / osteomyelitis |
49 M |
CAD, CHF, COPD, ESRD/HD, PVD |
52 |
Not able to identify |
Peritoneal fluid |
GI perforation, peritonitis |
37 M |
Kidney-pancreas transplant, DM |
11 |
E. faecium |
Blood |
Recurrent cholangitis |
49 M |
Kidney-pancreas transplant, DM |
12 |
E. faecium |
Blood |
Intraabdominal abscess after surgery |
2008 |
|
|
|
|
|
39 M |
Hydrocephalus, VPS |
25 |
E. faecium |
Peritoneal fluid |
GI perforation following MVA |
61F |
DM, endometrial malignancy |
No |
E. faecium |
Urine |
Pelvic exenteration, kidney abscess |
78 M |
CAD, CKD, CVA, DM |
No |
E. faecium |
Urinea |
Septic arthritis due viridans streptococci |
57 M |
Urinary bladder malignancy |
No |
E. faecium |
Peritoneal fluid |
Pelvic abscess after surgery |
2007 |
|
|
|
|
|
59 M |
MDS, BMT |
8 |
E. faecium |
Blood |
Neutropenic fever, GVHD of gut |
59F |
DM, ESRD/HD, VHD |
16 |
E. faecium |
Urinea |
Cryptococcal meningitis |
2006 |
|
|
|
|
|
6F |
Recurrent UTI |
No |
Not Available |
Urine |
UTI |
46F |
Cholangitis, DM, ESRD/HD |
No |
E. faecalis |
Blood |
Recurrent polymicrobial cholangitis |
62 M |
CAD, COPD |
No |
Not available |
Urinea |
Lumbar pain and sciatica |
2005 |
|
|
|
|
|
38 M |
DM, metastatic malignancy of colon |
No |
Not available |
Urine |
Chemotherapy, neutropenia, pyelonephritis |
35F | DM, gastroparesis | No | Not available | Urinea | Recurrent gastroparesis |
Patient characteristics, past medical history, daptomycin exposure history (total days in prior year), isolate species, isolate source, and abbreviated reason for admission and/or complications arising during index admission for the 25 patients identified to be colonized or infected with DNSE during the study period.
NOTE:
a – Represents DNSE colonization.
Abbreviations: ALL = acute lymphoblastic leukemia; AML = acute myelogenous leukemia; BMT = bone marrow transplant; CAD = coronary artery disease; CDI = Clostridium difficile infection; CHF = congestive heart failure; CKD = chronic kidney disease; COPD = chronic obstructive pulmonary disease; CVA = cerebro-vascular accident; DM = diabetes mellitus; ESRD/HD = end stage renal disease requiring hemodialysis; GI = gastrointestinal; GVHD = graft versus host disease; MDS = myelodysplastic syndrome; MVA = motor vehicle accident; PVD = peripheral vascular disease; SBO = small bowl obstruction; SCT = stem cell transplant; SSTI = skin and soft tissue infection; UTI = urinary tract infection; VHD = valvular heart disease; VPS = ventriculoperitoneal shunt; Pulmonary Htn = pulmonary hypertension.