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. 2012 May 29;1:19. doi: 10.1186/2047-2994-1-19

Table 1.

Clinical characteristics of patients with DNSE colonization or infection

Year, Age, Sex Past Medical History Total Days of Daptomycin Exposure Species Source Reason for Admission and/or Complications
2011
 
 
 
 
 
55F
MDS, SCT
5
E. faecium
Blood, urine
Neutropenia, GVHD of gut
55F
ALL, BMT, DM, PVD
No
E. faecium
Blood
Neutropenia, CDI
58F
Gynecological malignancy
9
E. faecium
Blood
GI inflammation due to metastatic disease
59F
AML
19
E. faecium
Blood
Neutropenia, appendicitis
51F
AML, SCT
29
E. faecium
Urinea
Neutropenia, colitis
2010
 
 
 
 
 
74F
MDS, SBO, CHF, Pulmonary Htn
10
E. faecium
Urinea
Small bowel resection, sepsis
80F
CAD, COPD, PVD
No
E. faecalis
Urinea
Bowel ischemia after surgery
42 M
DM, bipolar disorder
12
E. faecium
Wound, lumbar
Chronic lumbar abscess
56F
AML, SCT, DM
67
E. faecium
Blood
Neutropenia, sigmoid colon perforation
2009
 
 
 
 
 
50F
AML, SCT
20
E. faecium
Urinea
Neutropenia, GVHD of gut, colitis
50 M
DM, Hip SSTI/osteomyelitis
19
E. faecium
Wound, hip
Hip SSTI / osteomyelitis
49 M
CAD, CHF, COPD, ESRD/HD, PVD
52
Not able to identify
Peritoneal fluid
GI perforation, peritonitis
37 M
Kidney-pancreas transplant, DM
11
E. faecium
Blood
Recurrent cholangitis
49 M
Kidney-pancreas transplant, DM
12
E. faecium
Blood
Intraabdominal abscess after surgery
2008
 
 
 
 
 
39 M
Hydrocephalus, VPS
25
E. faecium
Peritoneal fluid
GI perforation following MVA
61F
DM, endometrial malignancy
No
E. faecium
Urine
Pelvic exenteration, kidney abscess
78 M
CAD, CKD, CVA, DM
No
E. faecium
Urinea
Septic arthritis due viridans streptococci
57 M
Urinary bladder malignancy
No
E. faecium
Peritoneal fluid
Pelvic abscess after surgery
2007
 
 
 
 
 
59 M
MDS, BMT
8
E. faecium
Blood
Neutropenic fever, GVHD of gut
59F
DM, ESRD/HD, VHD
16
E. faecium
Urinea
Cryptococcal meningitis
2006
 
 
 
 
 
6F
Recurrent UTI
No
Not Available
Urine
UTI
46F
Cholangitis, DM, ESRD/HD
No
E. faecalis
Blood
Recurrent polymicrobial cholangitis
62 M
CAD, COPD
No
Not available
Urinea
Lumbar pain and sciatica
2005
 
 
 
 
 
38 M
DM, metastatic malignancy of colon
No
Not available
Urine
Chemotherapy, neutropenia, pyelonephritis
35F DM, gastroparesis No Not available Urinea Recurrent gastroparesis

Patient characteristics, past medical history, daptomycin exposure history (total days in prior year), isolate species, isolate source, and abbreviated reason for admission and/or complications arising during index admission for the 25 patients identified to be colonized or infected with DNSE during the study period.

NOTE:

a – Represents DNSE colonization.

Abbreviations: ALL = acute lymphoblastic leukemia; AML = acute myelogenous leukemia; BMT = bone marrow transplant; CAD = coronary artery disease; CDI = Clostridium difficile infection; CHF = congestive heart failure; CKD = chronic kidney disease; COPD = chronic obstructive pulmonary disease; CVA = cerebro-vascular accident; DM = diabetes mellitus; ESRD/HD = end stage renal disease requiring hemodialysis; GI = gastrointestinal; GVHD = graft versus host disease; MDS = myelodysplastic syndrome; MVA = motor vehicle accident; PVD = peripheral vascular disease; SBO = small bowl obstruction; SCT = stem cell transplant; SSTI = skin and soft tissue infection; UTI = urinary tract infection; VHD = valvular heart disease; VPS = ventriculoperitoneal shunt; Pulmonary Htn = pulmonary hypertension.