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. 2012 May 1;6:29. doi: 10.1186/1752-0509-6-29

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Copyright ©2012 Kirouac et al.; licensee BioMed Central Ltd.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Ensemble network of inflammatory genes and interactions. The Ensemble network is represented as a mixed directed/undirected graph with 2,361 genes (nodes; color-coded by source, and size-coded by degree) and 63,276 non-redundant interactions (edges) (A). Genes comprising the network are functionally annotated using the GeneGo ontology, and categories rank ordered by relative proportion (B). Edges are functionally annotated as stimulatory, inhibitory, or undirected (C), and mechanistically annotated as direct protein-protein interactions (PPI) vs. indirect (Non-PPI) (D), based on a combination of annotations from the various sources.