Table 2.

Some important drugs that inhibit cytochrome P450 dependent CYP3A4 and CYP2D6

CYP2D6	CYP3A4
Antiarrhythmics (Flecainide, Propafenone, etc.)	Antiarrhythmics (Amiodarone, Lidocaine, Propafenone, etc.)
Beta blockers (Carvedilol, Metoprolol, etc..)	Anti-histamines (Astemizole, Chlorpheniramine)
Neuroleptics (Haloperidol, Risperidone, Clozapine, etc.)	Anti-cancer (Tamoxifen, Vinblastine)
Opiates (Dextromethorphan, Codeine, Tramadol, etc.)	Benzodiazepines (Midozalam, Diazepam, Alprazolam, etc.)
SSRI (Fluoxetine, Paroxetine, Fluvoxamine, etc.)	HIV-protease inh (Ritonavir, Indinavir, etc.)
Tricyclic antidepressants (Amitriptyline, Desipramine, Imipramine, Nortriptyline, etc.)	HMG CoA reductaseinh (Atorvastatin, Lovastatine, Simvastatin)
	Hormones (Cortisol, Progesterone, Testosterone, steroids)
	Calcium channel blocker (Diltiazem, Verapamil, Nitrendipin)
	Macrolides (Erythromycin, Clarithromycin)
	Others (Ketoconazole, Itraconazole, Lidocaine, Cocaine,…etc)