Table 3.
Accuracy of imputation for genotyping scenarios when removing subsets of individuals from the “Other” category
|
Scenario |
Genotyping strategy1 |
2Imputation accuracy: R-squared |
|||||||
|---|---|---|---|---|---|---|---|---|---|
| |
3Other |
Grandparents |
Parents |
Testing individuals |
|
||||
| |
MGS + PGS |
MGD + PGD |
Sire |
Dam |
|
|
|
|
|
| n2436 | n = 63 | n = 86 | n = 41 | n = 73 | n = 98 | L6k | L3k | L384 | |
|
s4_100% |
100 % H |
H |
L |
H |
L |
L |
.991 |
.985 |
.935 |
|
s4_50% |
50 % H |
H |
L |
H |
L |
L |
.991 |
.984 |
.927 |
|
s4_25% |
25 % H |
H |
L |
H |
L |
L |
.988 |
.981 |
.915 |
|
s5_100% |
100 % H |
H |
0 |
H |
0 |
L |
.981 |
.968 |
.888 |
|
s5_50% |
50 % H |
H |
0 |
H |
0 |
L |
.981 |
.968 |
.877 |
|
s5_25% |
25 % H |
H |
0 |
H |
0 |
L |
.979 |
.966 |
.871 |
|
s12_100% |
100 % H |
0 |
0 |
0 |
0 |
L |
.953 |
.931 |
.817 |
|
s12_50% |
50 % H |
0 |
0 |
0 |
0 |
L |
.941 |
.914 |
.778 |
| s12_25% | 25 % H | 0 | 0 | 0 | 0 | L | .917 | .879 | .759 |
1Animals were split into groups (ordered by generation) of testing individuals, their parents, and their grandparents; grandparents were further divided into two groups: MGS + PGS which included maternal grandsire and paternal grandsire, and MGD + PGD which included maternal granddam and paternal granddam; the remaining individuals were placed in the “Other” category; groups of animals were either genotyped at high density (H), low density (L) or not genotyped (0); 2Imputation accuracy (R-squared) for scenarios using SNP panels L6k, L3k and L384 on animals genotyped at low density; 3100 % H means that all of the individuals in the “Other” category are genotyped at high density, 50 % H means that only a random 50 % of the individuals in the “Other” category are genotyped at high density, 25 % H means that only a random 25 % of the individuals in the “Other” category are genotyped at high density.