Table 3. DNA damage response-associated genes regulated by rotenone.
| entrez | gene | fold c. (1 week) | fold c. (4 weeks) | repair mechanism | references | ||
| ID | symbol | 5 nM | 50 nM | 5 nM | 50 nM | (function) | |
| 545 | ATR | −1.1 | −1.2 | +2.2 | +2.2 | SSB, DSB (sensor, activator) | [39], [40] |
| 1111 | CHEK1 | −1.3 | −1.7 | +2.0 | +1.3 | SSB, DSB (sensor, effector) | [39], [40] |
| 5884 | RAD17 | −1.4 | −1.4 | +2.2 | +2.3 | SSB, DSB, BER, HR (sensor) | [39], [40] |
| 472 | ATM | −1.1 | −1.1 | +1.8 | +1.5 | DSB, (sensor, activator) | [39], [40] |
| 11200 | CHEK2 | +1.2 | +1.2 | +1.0 | +1.0 | DSB, (sensor, effector) | [39], [40] |
| 4361 | MRE11A | −1.6 | −1.7 | +2.0 | +1.9 | DSB, HR (sensor, mediator) | [39], [40], [68] |
| 10111 | RAD50 | −1.3 | −1.3 | +1.6 | +1.4 | DSB, HR (sensor, mediator) | [39], [40], [68] |
| 4683 | NBN | +1.0 | −1.2 | +1.6 | +1.4 | DSB, HR (sensor, mediator) | [39], [40], [68] |
| 51776 | ZAK | −1.7 | −1.7 | +2.7 | +2.4 | DSB, (activator, arrest) | [151] |
| 25788 | RAD54B | +1.0 | −1.3 | +2.0 | +2.2 | DSB, HR (helicase) | [152] |
| 5980 | REV3L | −1.1 | −1.2 | +2.2 | +4.2 | DSB, TLS, HR (polymerase) | [153] |
| 7486 | WRN | −1.1 | −1.3 | +3.0 | +1.4 | DSB, HR, TLS (helicase) | [154] |
| 51567 | TDP2 | −1.4 | −1.6 | +1.9 | +2.3 | DSB,NHEJ (phosphatase) | [68], [155] |
| 4750 | NEK1 | −1.5 | −1.5 | +2.4 | +3.2 | DSB, HR, TLS, MMR (kinase) | [156], [157] |
| 5887 | RAD23B | −1.2 | −1.5 | +2.0 | +2.2 | NER (proteasome) | [68] |
| 1161 | ERCC8 | −1.2 | −1.4 | +1.5 | +2.0 | NER (proteasome) | [68], [158] |
| 7507 | XPA | −1.5 | −1.6 | +1.6 | +2.7 | NER (DNA binding) | [68], [158] |
| 4436 | MSH2 | −1.0 | −1.3 | +1.2 | +1.1 | MMR (sensor) | [67], [69], [70] |
| 2956 | MSH6 | −1.2 | −1.3 | +1.5 | +1.2 | MMR (sensor) | [67], [69], [70] |
| 4437 | MSH3 | −1.3 | −1.5 | −1.1 | +1.1 | MMR (sensor) | [67], [69], [70] |
| 4992 | MLH1 | +1.2 | −1.2 | +2.0 | −3.3 | MMR, HR (sensor, repair) | [67], [69], [70] |
| 5395 | PMS2 | +1.4 | +1.4 | −1.1 | −1.1 | MMR, HR (repair) | [67], [69], [70] |
| 5378 | PMS1 | −1.3 | −1.3 | +1.4 | +2.2 | MMR, HR (repair) | [67], [69], [70] |
| 8930 | MBD4 | +1.2 | −1.1 | +1.7 | −1.5 | MMR, HR (sensor, repair) | [159] |
Abbreviations: BER: Base excision repair; DSB: DNA double strand break; HR: Homologous recombination; MMR: Mismatch repair; NHEJ: NHEJ: Non-homologous end-joining; NER: Nucleotide excision repair; SSB: DNA single strand break; TLS: Translesion. Changes likely to delay cell cycle are shown by numbers in italics; those likely to accelerate cell cycle are shown regular numbers; Emboldening indicates fold change (fold c.) is <2.