Fig. 6.
(A) Analysis of local minima for the comprehensive approach. Several local minima, indicated by dashed lines, have been identified by LHS. B and C: Likelihood profiles for k2 and k3. The green solid line represents the likelihood profile calculated with the standard approach and the blue one represents the profile around the optimum for the comprehensive approach. The red dashed line and the red asterisks denote a selected local minimum for the comprehensive approach with the switched parameter configuration