Table 5.
Top three models identified by Cox-MDR with main effect and without main effect
| With all 139 SNPs |
With 118 SNPs after removing 21 SNPs having strong main effect |
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| Models | TRBA | TSBA | Coeff. | P | P* | Models | TRBA | TSBA | Coeff. | P | P* |
| One-way | One-way | ||||||||||
| TYMS rs1004474 | 0.665 | 0.665 | 0.156 | 0.487 | 0.00037 | TYMS rs1004474 | 0.665 | 0.665 | 0.156 | 0.487 | 0.00037 |
| TYMS rs2847153 | 0.633 | 0.633 | 0.206 | 0.324 | 0.00194 | TYMS rs2847153 | 0.633 | 0.633 | 0.206 | 0.324 | 0.00194 |
| CDA rs10799647 | 0.629 | 0.630 | −0.723 | 0.076 | 0.00001 | CDA rs10799647 | 0.629 | 0.630 | −0.723 | 0.076 | 0.00001 |
| Two-way | Two-way | ||||||||||
| CDA rs12404655 and | 0.719 | 0.712 | −1.125 | 0.098 | 0.00001 | CDA rs12404655 and | 0.719 | 0.712 | −1.125 | 0.098 | 0.00001 |
| TYMS rs1004474 | TYMS rs1004474 | ||||||||||
| CDA rs532545 and | 0.705 | 0.704 | −0.216 | 0.591 | 0.00973 | CDA rs532545 and | 0.705 | 0.704 | −0.216 | 0.591 | 0.03013 |
| TYMS rs2847153 | TYMS rs2847153 | ||||||||||
| CDA rs10916824 and | 0.713 | 0.704 | −1.211 | 0.117 | 0.00138 | MTHER rs9651118 and | 0.721 | 0.703 | −0.714 | 0.038 | 0.00035 |
| TYMS rs1004474 | TYMS rs1004474 | ||||||||||
TRBA: Training balanced accuracy; TSBA: Testing balanced accuracy; Coeff.: the estimated effect size of the corresponding SNP effect; P: P-value of main and two-way interactions in the Cox regression model; P*: permutation P-value of main and two-way interaction effects.