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. 2012 Sep 7;7(9):e44615. doi: 10.1371/journal.pone.0044615

Figure 5. Ca2+ mediates the expression of RHAMM, phospho-AKT and p21.

Figure 5

(A) Cells were treated with ionomycin to increase intracellular Ca2+ levels, and the expression levels of ANXA4, LAMP2, RHAMM, phospho-AKT (Ser473), p21, and phospho-CDK1 (Thr161) were showed by immunoblotting. (B) The histogram shows the related levels of (A). The relative expressions of RHAMM (P<0.01), phospho-AKT (Ser473) (P<0.05) and p21 (P<0.01) were significantly different. Data are taken from three independent experiments (mean ± SD). *P<0.05, **P<0.01 vs. control treatment values.