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. 2012 Sep 7;7(9):e44267. doi: 10.1371/journal.pone.0044267

Figure 3. Microarray analysis of IFN inducible genes in IFN sensitive SKOV3 cells, moderately resistant HT1080 cells treated with IFN, U0126 or both.

Figure 3

(A) Venn diagrams from DNA microarray analysis showing global suppression of IFN-regulated genes in HT1080 cells compared to SKOV3 cells. Shown are the number of genes significantly upregulated (FDR <0.01) at 6 hours after IFN treatment in the SKOV3 vs. HT1080 cell lines. (B) Venn diagrams showing the number of genes significantly upregulated (FDR <0.01) in HT1080 cells following treatment with IFN, U0126 or both IFN and U0126 for 6 hours or 12 hours as indicated. (C) Venn diagrams comparing genes upregulated by “protective” treatments in each cell type (IFN for SKOV3 cells and IFN/U0126 for HT1080 cells).