Table 1. Sensitivity of human cancer cell lines to IFN as measured by antiviral assay.
Sensitive | Moderately Resistant | Completely Resistant |
(IFNCPE50 a <10 U/ml) | (IFNCPE50 10–5000 U/ml) | (IFNCPE50>5000 U/ml) |
HeLa | A375 (ED50: 1695 U/ml) | DU145 |
SKBR3 | DLD-1 (ED50: 40 U/ml) | HCT116 |
SKOV3 | HT29 (ED50: 51 U/ml) | LNCaP |
HTB129 (ED50: 28 U/ml) | PA-1 | |
HT1080 (ED50: 219U/ml) | ||
MCF7 (ED50: 46 U/ml) | ||
MDAH (Ed50: 114 U/ml) | ||
MDA-MB468 (ED50: 27 U/ml) | ||
SW48 (Ed50: 3587 U/ml) |
IFN concentration that elicits a 50% protection against VSV infection based on analysis of cytopathic effects (CPE).