Table 1. Clinicophenotypical Correlation of markers in nineteen Cases of RB and expression fold change of miR 17–92 clusters in each tumor relative to normal retina as quantified by QPCR.
| Serial No | Age/sex | Clinicopathological features | miR-17 | miR-18a | miR-19b | miR-20a | miR-92 |
|---|---|---|---|---|---|---|---|
| 1 |
2 y/M |
OS,unilateral, PD, prelaminar & post laminar invasion of ON, scleral invasion |
25 |
120 |
13 |
36 |
45 |
| 2 |
1 y/M |
OD, unilateral,WD, prelaminar & laminar invasion of ON |
15 |
206 |
4 |
38 |
70 |
| 3 |
3 y/F |
OS, unilateral,MD, prelaminar and post laminar ON invasion |
45 |
290 |
19 |
25 |
26 |
| 4 |
2 y/M |
OD, PD, focal choroidal invasion < 3 mm |
65 |
225 |
36 |
34 |
45 |
| 5 |
2 y/F |
OD, PD, minimal prelaminar invasion of ON |
43 |
70 |
11 |
22 |
2 |
| 6 |
4 y/M |
OD, unilateral,MD, prelaminar & post laminar invasion of ON |
40 |
201 |
32 |
38 |
72 |
| 7 |
7 y/F |
OS, unilateral,PD, No invasion of choroid and ON |
35 |
156 |
17 |
32 |
38 |
| 8 |
3 y/M |
OS, unilateral,PD, No invasion of choroid and ON |
75 |
368 |
29 |
50 |
38 |
| 9 |
8 y/F |
OS, unilateral,PD, focal choroidal invasion <3 mm |
44 |
78 |
32 |
41 |
32 |
| 10 |
9 y/F |
OD, unilateral, PD, post laminar invasion of ON. |
68 |
301 |
15 |
65 |
71 |
| 11 |
2 y/M |
OS, unilateral,PD, prelaminar & post laminar invasion of ON, scleral invasion |
26 |
299 |
19 |
32 |
4 |
| 12 |
1 y/F |
OS, unilateral,WD, prelaminar invasion of ON |
65 |
167 |
26 |
15 |
32 |
| 13 |
2 y/M |
OS, unilateral,PD, focal choroidal invasion <3 mm |
51 |
100 |
39 |
22 |
15 |
| 14 |
5 Mon/M |
OD, unilateral,PD, diffuse choroidal invasion > 3 mm & pre laminar/laminar ON invasion |
40 |
179 |
36 |
40 |
2 |
| 15 |
4 y/M |
OD, unilateral,PD, focal RPE and focal choroidal invasion < 3 mm. |
20 |
255 |
24 |
45 |
68 |
| 16 |
2 y/M |
OS, bilateral, PD, focal choroidal and pre laminar ON invasion |
46 |
370 |
38 |
52 |
17 |
| 17 |
7 1/2 Mon/M |
OD, unilateral, WD, focal choroidal invasion < 3 mm with pre and post laminar ON invasion. |
49 |
320 |
29 |
49 |
28 |
| 18 |
32 Mon/M |
OD, unilateral,PD, no invasion of choroid and ON |
34 |
300 |
24 |
59 |
43 |
| 19 | 6 y/M | OD, unilateral,MD, full thickness choroidal invasion > 3mm | 69 | 175 | 34 | 64 | 11 |
Abbreviations: M: Male; F: Female; Mon: months; Y: years; OD: right eye; OS: left eye; ON: optic nerve; PD: poorly differentiated; MD: moderately differentiated; WD: well differentiated.