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. Author manuscript; available in PMC: 2013 Oct 1.
Published in final edited form as: J Bone Miner Res. 2012 Oct;27(10):2130–2143. doi: 10.1002/jbmr.1669

Figure 5. Effects of alendronate (ALN) and zoledronic acid (ZOL) on mandibular alveolar bone formation, osteoclast number and vascularity after 6-18 wks of treatments in rice rats.

Figure 5

A histomorphometric analysis was performed in the mandibles of male rats treated with vehicle, ALN, or a low dose (LD) (8 μg/kg) or high dose (HD) of ZOL (80 μg/kg) for 6, 12 and 18 wks. Mineralizing surface (A), mineral apposition rate (B), bone formation rate (C), osteoclast number (D) and blood vessel number (E). All measurements were performed within the ROI described in supplemental Figure 1. An asterisk denotes a significant difference from its respective time-matched vehicle-treated group. (P < 0.05).