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. Author manuscript; available in PMC: 2013 Sep 15.
Published in final edited form as: Free Radic Biol Med. 2012 Jul 20;53(6):1346–1357. doi: 10.1016/j.freeradbiomed.2012.07.005

Fig. 4. Inhibition of autophagy promotes binge ethanol-induced liver injury and steatosis.

Fig. 4

Fig. 4

CYP2E1 KI, and KO mice were gavaged with ethanol in the absence or presence of 100 mg/kg body wt, 3MA or 5 mg/kg rapamycin once a day for 4 days. Serum ALT and AST (A). *,**, P<0.05 compared with ethanol alone, #, P<0.05 compared with saline group. N=4. Liver H&E staining in KI, 100× magnification (B) or KO mice, 100× magnification (C); liver TG content (D). *, P<0.05 compared with saline mice; **, #, P<0.05 compared with ethanol alone. N=4.