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. Author manuscript; available in PMC: 2013 Sep 15.
Published in final edited form as: J Immunol. 2012 Aug 17;189(6):2918–2930. doi: 10.4049/jimmunol.1200065

FIGURE 7.

FIGURE 7

The CD5-CK2 signaling pathway differentially affects Th1 and Th17 EAE. Th1 and Th17 EAE were induced by passive transfer of encephalitogenic CD5WT, CD5KO, or CD5ΔCK2BD T-cells. Splenocytes from immunized donor mice of each CD5 genotype were depleted of CD8+ and CD25+ cells and re-stimulated under Th1 (A) and Th17 (B) polarizing conditions with MOG35-55 peptide for 72 h. Cells were transferred to sublethally irradiated CD5WT mice to induce disease. Data±SEM are from two separate experiments, 6-11 mice per group. Bar above plot denote region of statistical significance. *p<0.05, **p<0.01 with Student t test.