Skip to main content
. Author manuscript; available in PMC: 2013 Sep 15.
Published in final edited form as: J Immunol. 2012 Aug 6;189(6):2824–2832. doi: 10.4049/jimmunol.1201114

Figure 8.

Figure 8

Effect of GRK6 knockdown in leukocyte migration, myeloperoxidase (MPO) activity and wound re-epithelialization. A) Six-day air pouches were raised in the dorsum of 6–8 week old GRK6−/− mice and their littermates (GRK6+/+). Mice were injected with 0.5 ml PBS or PBS containing murine CXCL1 (100 pmol). Exudates were collected after 4 h and the total number of leukocytes (~90% neutrophils) was enumerated. *P<0.05, Student’s t test. B) Wound extracts from GRK6−/− and wild type GRK6+/+ mice were harvested and MPO activity within each wound bed was determined spectrophotometrically. The mean ± SEM value of four wounds for each time point of each mouse genotype is shown. Statistical difference is evaluated by Student’s t test. *P<0.05. C) Percentage of epidermal re-surfacing for wounds from wild type GRK6+/+ and GRK6−/− animals were measured at days 3, 5, 7 and 10 as described in Materials and Methods. The value of each time point was obtained from 8 wounds and is expressed as mean ± SEM. ** p<0.01 by Student’s t-test.