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. Author manuscript; available in PMC: 2013 Sep 1.
Published in final edited form as: Clin Perinatol. 2012 Sep;39(3):441–457. doi: 10.1016/j.clp.2012.06.010

Figure 3.

Figure 3

Intra-amniotic Ureaplasma given 70d prior to a 2nd intra-amniotic exposure to E. coli lipopolysaccharide (LPS) suppressed the LPS responses in lungs of preterm fetal sheep. The chronic fetal exposure to Ureaplasma (A) suppressed IL-1β mRNA in the fetal lung, (B) decreased recruitment of myeloperoxidase positive cells (MPO) to the lung, (C) prevented the expression of the macrophage maturation transcription factor PU.1 in lung, and (D) decreased the release of IL-6 from blood monocytes challenged in culture with LPS. Data from Kallapur, et al..(71)