Figure 4.
Indicators of lung maturation following intra-amniotic E. coli lipopolysaccharide (LPS) and/or maternal betamethasone (Beta) given 7 or 14d prior to preterm delivery at 120d gestational age. (A,B) The indicators surfactant protein-D (SP-D), and saturated (Sat) phosphatidylcholine in bronchoalveolar lavage fluid (BALF) increased with LPS exposure, but increased more when the order of exposure was LPS given 14d and Beta given 7d before delivery. (C) The lung gas volumes measured with air inflation to 40 cm H2O pressure reflected the amounts of saturated phosphatidylcholine. Data from Kuypers, et al. (54). *p<0.05 relative to control tP<0.05 LPS/Beta relative to Beta/LPS